Multiple quantum filtered 23Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]i
Identifieur interne : 000123 ( Main/Exploration ); précédent : 000122; suivant : 000124Multiple quantum filtered 23Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]i
Auteurs : Thomas R. Eykyn [Royaume-Uni] ; Dunja Aksentijevi [Royaume-Uni] ; Karen L. Aughton [Royaume-Uni] ; Richard Southworth [Royaume-Uni] ; William Fuller [Royaume-Uni] ; Michael J. Shattock [Royaume-Uni]Source :
- Journal of Molecular and Cellular Cardiology [ 0022-2828 ] ; 2015.
Abstract
We investigate the potential of multiple quantum filtered (MQF) 23Na NMR to probe intracellular [Na]i in the Langendorff perfused mouse heart. In the presence of Tm(DOTP) shift reagent the triple quantum filtered (TQF) signal originated largely from the intracellular sodium pool with a 32 ± 6% contribution of the total TQF signal arising from extracellular sodium, whilst the rank 2 double-quantum filtered signal (DQF), acquired with a 54.7° flip-angle pulse, originated exclusively from the extracellular sodium pool. Given the different cellular origins of the 23Na MQF signals we propose that the TQF/DQF ratio can be used as a semi-quantitative measure of [Na]i in the mouse heart. We demonstrate a good correlation of this ratio with [Na]i measured with shift reagent at baseline and under conditions of elevated [Na]i. We compare the measurements of [Na]i using both shift reagent and TQF/DQF ratio in a cohort of wild type mouse hearts and in a transgenic PLM3SA mouse expressing a non-phosphorylatable form of phospholemman, showing a modest but measurable elevation of baseline [Na]i. MQF filtered 23Na NMR is a potentially useful tool for studying normal and pathophysiological changes in [Na]i, particularly in transgenic mouse models with altered Na regulation.
Url:
DOI: 10.1016/j.yjmcc.2015.07.009
PubMed: 26196304
PubMed Central: 4564289
Affiliations:
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Aughton</name><affiliation wicri:level="1"><nlm:aff id="af0010">The British Heart Foundation Centre of Research Excellence, The Rayne Institute, King's College London, St. Thomas' Hospital, London SE1 7EH, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The British Heart Foundation Centre of Research Excellence, The Rayne Institute, King's College London, St. Thomas' Hospital, London SE1 7EH</wicri:regionArea><wicri:noRegion>London SE1 7EH</wicri:noRegion></affiliation></author><author><name sortKey="Southworth, Richard" sort="Southworth, Richard" uniqKey="Southworth R" first="Richard" last="Southworth">Richard Southworth</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Imaging Chemistry and Biology, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London SE1 7EH, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Imaging Chemistry and Biology, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London SE1 7EH</wicri:regionArea><wicri:noRegion>London SE1 7EH</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af0010">The British Heart Foundation Centre of Research Excellence, The Rayne Institute, King's College London, St. Thomas' Hospital, London SE1 7EH, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The British Heart Foundation Centre of Research Excellence, The Rayne Institute, King's College London, St. Thomas' Hospital, London SE1 7EH</wicri:regionArea><wicri:noRegion>London SE1 7EH</wicri:noRegion></affiliation></author><author><name sortKey="Fuller, William" sort="Fuller, William" uniqKey="Fuller W" first="William" last="Fuller">William Fuller</name><affiliation wicri:level="1"><nlm:aff id="af0015">Division of Cardiovascular and Diabetes Medicine, University of Dundee, Dundee, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular and Diabetes Medicine, University of Dundee, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Shattock, Michael J" sort="Shattock, Michael J" uniqKey="Shattock M" first="Michael J." last="Shattock">Michael J. Shattock</name><affiliation wicri:level="1"><nlm:aff id="af0010">The British Heart Foundation Centre of Research Excellence, The Rayne Institute, King's College London, St. Thomas' Hospital, London SE1 7EH, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The British Heart Foundation Centre of Research Excellence, The Rayne Institute, King's College London, St. Thomas' Hospital, London SE1 7EH</wicri:regionArea><wicri:noRegion>London SE1 7EH</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Molecular and Cellular Cardiology</title><idno type="ISSN">0022-2828</idno><idno type="eISSN">1095-8584</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We investigate the potential of multiple quantum filtered (MQF) <sup>23</sup>Na NMR to probe intracellular [Na]<sub>i</sub> in the Langendorff perfused mouse heart. In the presence of Tm(DOTP) shift reagent the triple quantum filtered (TQF) signal originated largely from the intracellular sodium pool with a 32 ± 6% contribution of the total TQF signal arising from extracellular sodium, whilst the rank 2 double-quantum filtered signal (DQF), acquired with a 54.7° flip-angle pulse, originated exclusively from the extracellular sodium pool. Given the different cellular origins of the <sup>23</sup>Na MQF signals we propose that the TQF/DQF ratio can be used as a semi-quantitative measure of [Na]<sub>i</sub> in the mouse heart. We demonstrate a good correlation of this ratio with [Na]<sub>i</sub> measured with shift reagent at baseline and under conditions of elevated [Na]<sub>i</sub>. We compare the measurements of [Na]<sub>i</sub> using both shift reagent and TQF/DQF ratio in a cohort of wild type mouse hearts and in a transgenic PLM<sup>3SA</sup> mouse expressing a non-phosphorylatable form of phospholemman, showing a modest but measurable elevation of baseline [Na]<sub>i</sub>. MQF filtered <sup>23</sup>Na NMR is a potentially useful tool for studying normal and pathophysiological changes in [Na]<sub>i</sub>, particularly in transgenic mouse models with altered Na regulation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Murphy, E" uniqKey="Murphy E">E. Murphy</name></author><author><name sortKey="Eisner, D A" uniqKey="Eisner D">D.A. Eisner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Despa, S" uniqKey="Despa S">S. Despa</name></author><author><name sortKey="Bers, D M" uniqKey="Bers D">D.M. 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Gupta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imahashi, K" uniqKey="Imahashi K">K. Imahashi</name></author><author><name sortKey="London, R E" uniqKey="London R">R.E. London</name></author><author><name sortKey="Steenbergen, C" uniqKey="Steenbergen C">C. Steenbergen</name></author><author><name sortKey="Murphy, E" uniqKey="Murphy E">E. Murphy</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Eykyn, Thomas R" sort="Eykyn, Thomas R" uniqKey="Eykyn T" first="Thomas R." last="Eykyn">Thomas R. Eykyn</name></noRegion><name sortKey="Aksentijevi, Dunja" sort="Aksentijevi, Dunja" uniqKey="Aksentijevi D" first="Dunja" last="Aksentijevi">Dunja Aksentijevi</name><name sortKey="Aughton, Karen L" sort="Aughton, Karen L" uniqKey="Aughton K" first="Karen L." last="Aughton">Karen L. Aughton</name><name sortKey="Eykyn, Thomas R" sort="Eykyn, Thomas R" uniqKey="Eykyn T" first="Thomas R." last="Eykyn">Thomas R. Eykyn</name><name sortKey="Fuller, William" sort="Fuller, William" uniqKey="Fuller W" first="William" last="Fuller">William Fuller</name><name sortKey="Shattock, Michael J" sort="Shattock, Michael J" uniqKey="Shattock M" first="Michael J." last="Shattock">Michael J. Shattock</name><name sortKey="Southworth, Richard" sort="Southworth, Richard" uniqKey="Southworth R" first="Richard" last="Southworth">Richard Southworth</name><name sortKey="Southworth, Richard" sort="Southworth, Richard" uniqKey="Southworth R" first="Richard" last="Southworth">Richard Southworth</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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